Effective Small Molecule Antibacterials from a Novel Anti-Protein Secretion Screen

Effective Small Molecule Antibacterials from a Novel Anti-Protein Secretion Screen

The increasing problem of bacterial resistance to antibiotics underscores the urgent need for new antibacterials. Protein export pathways are attractive potential targets. The Sec pathway is essential for bacterial viability and includes components that are absent from eukaryotes. Here, we used a ne...

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Bibliographic Details
Main Authors: Mohamed Belal Hamed, Ewa Burchacka, Liselotte Angus, Arnaud Marchand, Jozefien De Geyter, Maria S. Loos, Jozef Anné, Hugo Klaassen, Patrick Chaltin, Spyridoula Karamanou, Anastassios Economou
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Microorganisms
Subjects:
<i>E. coli</i>
alkaline phosphatase
small molecule inhibitors
antibacterials
protein secretion
Online Access:https://www.mdpi.com/2076-2607/9/3/592

Internet

https://www.mdpi.com/2076-2607/9/3/592

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