STAT3-Mediated Transcriptional Regulation of Osteopontin in STAT3 Loss-of-Function Related Hyper IgE Syndrome

STAT3-Mediated Transcriptional Regulation of Osteopontin in STAT3 Loss-of-Function Related Hyper IgE Syndrome

BackgroundHyper-IgE syndrome (HIES) caused by loss-of-function (LOF) mutations in STAT3 gene (STAT3 LOF HIES) is associated with dental and facial abnormalities in addition to immunological defects. The role of STAT3 in the pathogenesis of the dental/facial features is, however, poorly elucidated.Ob...

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Bibliographic Details
Main Authors: Shubham Goel, Smrity Sahu, Ranjana W. Minz, Surjit Singh, Deepti Suri, Young M. Oh, Amit Rawat, Shobha Sehgal, Biman Saikia
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
craniosynostosis
dental anomalies
hyper-IgE syndrome
osteopontin
STAT3 signaling
skeletal anomalies
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.01080/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.01080/full

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