A Novel Heat Shock Element (HSE) in Entamoeba histolytica that Regulates the Transcriptional Activation of the EhPgp5 Gene in the Presence of Emetine Drug

A Novel Heat Shock Element (HSE) in Entamoeba histolytica that Regulates the Transcriptional Activation of the EhPgp5 Gene in the Presence of Emetine Drug

Transcriptional regulation of the multidrug resistance EhPgp5 gene in Entamoeba histolytica is induced by emetine stress. EhPgp5 overexpression alters the chloride-dependent currents that cause trophozoite swelling, diminishing induced programmed cell death (PCD) susceptibility. In contrast, antisen...

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Bibliographic Details
Main Authors: Alma Nieto, David G. Pérez Ishiwara, Esther Orozco, Virginia Sánchez Monroy, Consuelo Gómez García
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
multidrug resistance
HSE
Entamoeba histolytica
EhPgp5
emetine
stress
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2017.00492/full

Internet

http://journal.frontiersin.org/article/10.3389/fcimb.2017.00492/full

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