Human immunodeficiency virus envelope protein Gp120 induces proliferation but not apoptosis in osteoblasts at physiologic concentrations.

Patients with HIV infection have decreased numbers of osteoblasts, decreased bone mineral density and increased risk of fracture compared to uninfected patients; however, the molecular mechanisms behind these associations remain unclear. We questioned whether Gp120, a component of the envelope prote...

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Bibliographic Details
Main Authors: Nathan W Cummins, Anna Klicpera, Amy M Sainski, Gary D Bren, Sundeep Khosla, Jennifer J Westendorf, Andrew D Badley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3171487?pdf=render