Magnesium Restores Activity to Peripheral Blood Cells in a Patient With Functionally Impaired Interleukin-2-Inducible T Cell Kinase

Magnesium Restores Activity to Peripheral Blood Cells in a Patient With Functionally Impaired Interleukin-2-Inducible T Cell Kinase

Interleukin-2-inducible T cell kinase (ITK) is critical for T cell signaling and cytotoxicity, and control of Epstein-Barr virus (EBV). We identified a patient with a novel homozygous missense mutation (D540N) in a highly conserved residue in the kinase domain of ITK who presented with EBV-positive...

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Bibliographic Details
Main Authors: Matthew K. Howe, Kennichi Dowdell, Amitava Roy, Julie E. Niemela, Wyndham Wilson, Joshua J. McElwee, Jason D. Hughes, Jeffrey I. Cohen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
IL-2 inducible T cell kinase
ITK
Epstein-Barr virus
lymphomatoid granulomatosis
magnesium
immunodeficiency
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02000/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02000/full

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