Pathogenic tau modifications occur in axons before the somatodendritic compartment in mossy fiber and Schaffer collateral pathways

Pathogenic tau modifications occur in axons before the somatodendritic compartment in mossy fiber and Schaffer collateral pathways

Abstract The deposition of tau pathology in Alzheimer’s disease (AD) may occur first in axons of neurons and then progress back into the cell bodies to form neurofibrillary tangles, however, studies have not directly analyzed this relationship in relatively discrete circuits within the human hippoca...

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Bibliographic Details
Main Authors: Kyle R. Christensen, Thomas G. Beach, Geidy E. Serrano, Nicholas M. Kanaan
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Acta Neuropathologica Communications
Subjects:
AT8 phosphoepitope
Conformation
Phosphorylation
Alzheimer’s disease
Tauopathies
Axonal degeneration
Online Access:http://link.springer.com/article/10.1186/s40478-019-0675-9

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http://link.springer.com/article/10.1186/s40478-019-0675-9

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