The miR-23a~27a~24-2 microRNA cluster buffers transcription and signaling pathways during hematopoiesis.

The miR-23a~27a~24-2 microRNA cluster buffers transcription and signaling pathways during hematopoiesis.

MicroRNA cluster mirn23a has previously been shown to promote myeloid development at the expense of lymphoid development in overexpression and knockout mouse models. This polarization is observed early in hematopoietic development, with an increase in common lymphoid progenitors (CLPs) and a decreas...

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Bibliographic Details
Main Authors: Jeffrey L Kurkewich, Justin Hansen, Nathan Klopfenstein, Helen Zhang, Christian Wood, Austin Boucher, Joseph Hickman, David E Muench, H Leighton Grimes, Richard Dahl
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-07-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC5531666?pdf=render

Internet

http://europepmc.org/articles/PMC5531666?pdf=render

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