Multiple interaction nodes define the postreplication repair response to UV‐induced DNA damage that is defective in melanomas and correlated with UV signature mutation load

Multiple interaction nodes define the postreplication repair response to UV‐induced DNA damage that is defective in melanomas and correlated with UV signature mutation load

Ultraviolet radiation‐induced DNA mutations are a primary environmental driver of melanoma. The reason for this very high level of unrepaired DNA lesions leading to these mutations is still poorly understood. The primary DNA repair mechanism for UV‐induced lesions, that is, the nucleotide excision r...

Full description

Bibliographic Details
Main Authors: Sandra Pavey, Alex Pinder, Winnie Fernando, Nicholas D’Arcy, Nicholas Matigian, Dubravka Skalamera, Kim‐Anh Lê Cao, Dorothy Loo‐Oey, Michelle M. Hill, Mitchell Stark, Michael Kimlin, Andrew Burgess, Nicole Cloonan, Richard A. Sturm, Brian Gabrielli
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Molecular Oncology
Subjects:
DNA repair
G2 phase checkpoint
MASTL
postreplication repair
ultraviolet radiation
Online Access:https://doi.org/10.1002/1878-0261.12601

Internet

https://doi.org/10.1002/1878-0261.12601

Similar Items