Conformation-Dependent High-Affinity Potent Ricin-Neutralizing Monoclonal Antibodies

Ricin is a potential biothreat agent with no approved antidote available for ricin poisoning. The aim of this study was to develop potent antibody-based antiricin antidotes. Four strong ricin resistant hybridoma clones secreting antiricin monoclonal antibodies (mAbs) were developed. All four mAbs ar...

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Bibliographic Details
Main Authors: Wei-Gang Hu, Junfei Yin, Damon Chau, Charles Chen Hu, Dustin Lillico, Justin Yu, Laurel M. Negrych, John W. Cherwonogrodzky
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2013/471346