Mkrn2 deficiency induces teratozoospermia and male infertility through p53/PERP-mediated apoptosis in testis

Mkrn2 deficiency induces teratozoospermia and male infertility through p53/PERP-mediated apoptosis in testis

The apoptosis that occurs in the immature testis under physiological conditions is necessary for male germ cell development, whereas improper activation of apoptosis can impair spermatogenesis and cause defects in reproduction. We previously demonstrated that in mice, the makorin-2 (Mkrn 2) gene is...

Full description

Bibliographic Details
Main Authors: Ying-Chen Qian, Yun-Xia Xie, Chao-Shan Wang, Zhu-Mei Shi, Cheng-Fei Jiang, Yun-Yi Tang, Xu Qian, Lin Wang, Bing-Hua Jiang
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2020-01-01
Series:Asian Journal of Andrology
Subjects:
apoptosis; makorin-2; p53; p53 apoptosis effector related to pmp22; spermatogenesis
Online Access:http://www.ajandrology.com/article.asp?issn=1008-682X;year=2020;volume=22;issue=4;spage=414;epage=421;aulast=Qian

Internet

http://www.ajandrology.com/article.asp?issn=1008-682X;year=2020;volume=22;issue=4;spage=414;epage=421;aulast=Qian

Similar Items