p19INK4d Controls Hematopoietic Stem Cells in a Cell-Autonomous Manner during Genotoxic Stress and through the Microenvironment during Aging

p19INK4d Controls Hematopoietic Stem Cells in a Cell-Autonomous Manner during Genotoxic Stress and through the Microenvironment during Aging

Hematopoietic stem cells (HSCs) are characterized by the capacity for self-renewal and the ability to reconstitute the entire hematopoietic compartment. Thrombopoietin maintains adult HSCs in a quiescent state through the induction of cell cycle inhibitors p57Kip2 and p19INK4d. Using the p19INK4d−/−...

Full description

Bibliographic Details
Main Authors: Morgane Hilpert, Céline Legrand, Dominique Bluteau, Natalie Balayn, Aline Betems, Olivier Bluteau, Jean-Luc Villeval, Fawzia Louache, Patrick Gonin, Najet Debili, Isabelle Plo, William Vainchenker, Laure Gilles, Hana Raslova
Format: Article
Language:English
Published: Elsevier 2014-12-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671114003270

Similar Items

Similar Items