Regulation of Platelet Production and Life Span: Role of Bcl-xL and Potential Implications for Human Platelet Diseases

by Emma C. Josefsson, William Vainchenker, Chloe James
Published 2020-10-01

Recent advances in understanding myelofibrosis and essential thrombocythemia [version 1; referees: 2 approved]

by William Vainchenker, Stefan N. Constantinescu, Isabelle Plo
Published 2016-04-01

Functional Consequences of Mutations in Myeloproliferative Neoplasms

by Stefan N. Constantinescu, William Vainchenker, Gabriel Levy, Nicolas Papadopoulos
Published 2021-06-01

Identification of MPL R102P Mutation in Hereditary Thrombocytosis

by Christine Bellanné-Chantelot, Christine Bellanné-Chantelot, Matthieu Mosca, Matthieu Mosca, Matthieu Mosca, Caroline Marty, Caroline Marty, Caroline Marty, Rémi Favier, Rémi Favier, William Vainchenker, William Vainchenker, William Vainchenker, Isabelle Plo, Isabelle Plo, Isabelle Plo
Published 2017-09-01

Genetic Alterations of the Thrombopoietin/MPL/JAK2 Axis Impacting Megakaryopoiesis

by Isabelle Plo, Isabelle Plo, Isabelle Plo, Christine Bellanné-Chantelot, Christine Bellanné-Chantelot, Matthieu Mosca, Matthieu Mosca, Matthieu Mosca, Stefania Mazzi, Stefania Mazzi, Stefania Mazzi, Caroline Marty, Caroline Marty, Caroline Marty, William Vainchenker, William Vainchenker, William Vainchenker
Published 2017-09-01

JAK inhibitors for the treatment of myeloproliferative neoplasms and other disorders [version 1; referees: 2 approved]

by William Vainchenker, Emilie Leroy, Laure Gilles, Caroline Marty, Isabelle Plo, Stefan N. Constantinescu
Published 2018-01-01

A senescence-like cell-cycle arrest occurs during megakaryocytic maturation: implications for physiological and pathological megakaryocytic proliferation.

by Rodolphe Besancenot, Ronan Chaligné, Carole Tonetti, Florence Pasquier, Caroline Marty, Yann Lécluse, William Vainchenker, Stefan N Constantinescu, Stéphane Giraudier
Published 2010-09-01

The Notch Delta-4 ligand helps to maintain the quiescence and the short-term reconstitutive potential of haematopoietic progenitor cells through activation of a key gene network

by Cyril Catelain, Fabio Michelet, Aurore Hattabi, Sonia Poirault-Chassac, Thierry Kortulewski, Diana Tronik-Le Roux, William Vainchenker, Evelyne Lauret
Published 2014-11-01

p19INK4d Controls Hematopoietic Stem Cells in a Cell-Autonomous Manner during Genotoxic Stress and through the Microenvironment during Aging

by Morgane Hilpert, Céline Legrand, Dominique Bluteau, Natalie Balayn, Aline Betems, Olivier Bluteau, Jean-Luc Villeval, Fawzia Louache, Patrick Gonin, Najet Debili, Isabelle Plo, William Vainchenker, Laure Gilles, Hana Raslova
Published 2014-12-01

MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors

by Malik Lutzmann, Florence Bernex, Cindy da Costa de Jesus, Dana Hodroj, Caroline Marty, Isabelle Plo, William Vainchenker, Marie Tosolini, Luc Forichon, Caroline Bret, Sophie Queille, Candice Marchive, Jean-Sébastien Hoffmann, Marcel Méchali
Published 2019-09-01

Calreticulin del52 and ins5 knock-in mice recapitulate different myeloproliferative phenotypes observed in patients with MPN

by Camélia Benlabiod, Maira da Costa Cacemiro, Audrey Nédélec, Valérie Edmond, Delphine Muller, Philippe Rameau, Laure Touchard, Patrick Gonin, Stefan N. Constantinescu, Hana Raslova, Jean-Luc Villeval, William Vainchenker, Isabelle Plo, Caroline Marty
Published 2020-09-01

TET2 haploinsufficiency alters reprogramming into induced pluripotent stem cells

by Lise Secardin, Cintia Elisabeth Gomez Limia, Antonio di Stefano, Martin Hernan Bonamino, Joseph Saliba, Keisuke Kataoka, Stevens K. Rehen, Hana Raslova, Caroline Marty, Seishi Ogawa, William Vainchenker, Barbara da Costa Reis Monte-Mor, Isabelle Plo
Published 2020-04-01

Induced Pluripotent Stem Cells Enable Disease Modeling and Drug Screening in Calreticulin del52 and ins5 Myeloproliferative Neoplasms

by Lise Secardin, Cintia Gomez Limia, Suzana da Silva-Benedito, Larissa Lordier, Mira El-Khoury, Caroline Marty, Jean-Christophe Ianotto, Hana Raslova, Stefan N. Constantinescu, Martín Hernán Bonamino, William Vainchenker, Barbara Monte-Mor, Antonio Di Stefano, Isabelle Plo
Published 2021-07-01

The Pediatric Acute Leukemia Fusion Oncogene ETO2-GLIS2 Increases Self-Renewal and Alters Differentiation in a Human Induced Pluripotent Stem Cells-Derived Model

by Salvatore Nicola Bertuccio, Fabien Boudia, Marie Cambot, Cécile K. Lopez, Larissa Lordier, Alessandro Donada, Elie Robert, Cécile Thirant, Zakia Aid, Salvatore Serravalle, Annalisa Astolfi, Valentina Indio, Franco Locatelli, Andrea Pession, William Vainchenker, Riccardo Masetti, Hana Raslova, Thomas Mercher
Published 2020-02-01

Heterozygous and homozygous JAK2(V617F) states modeled by induced pluripotent stem cells from myeloproliferative neoplasm patients.

by Joseph Saliba, Sofiane Hamidi, Gaëlle Lenglet, Thierry Langlois, Jingkui Yin, Xénia Cabagnols, Lise Secardin, Céline Legrand, Anne Galy, Paule Opolon, Baya Benyahia, Eric Solary, Olivier A Bernard, Longyun Chen, Najet Debili, Hana Raslova, Françoise Norol, William Vainchenker, Isabelle Plo, Antonio Di Stefano
Published 2013-01-01

Critical role of the HDAC6–cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect

by Kahia Messaoudi, Ashfaq Ali, Rameez Ishaq, Alberta Palazzo, Dominika Sliwa, Olivier Bluteau, Sylvie Souquère, Delphine Muller, Khadija M. Diop, Philippe Rameau, Valérie Lapierre, Jean-Pierre Marolleau, Patrick Matthias, Isabelle Godin, Gérard Pierron, Steven G. Thomas, Stephen P. Watson, Nathalie Droin, William Vainchenker, Isabelle Plo, Hana Raslova, Najet Debili
Published 2017-11-01

Mutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents

by Jane Merlevede, Nathalie Droin, Tingting Qin, Kristen Meldi, Kenichi Yoshida, Margot Morabito, Emilie Chautard, Didier Auboeuf, Pierre Fenaux, Thorsten Braun, Raphael Itzykson, Stéphane de Botton, Bruno Quesnel, Thérèse Commes, Eric Jourdan, William Vainchenker, Olivier Bernard, Noemie Pata-Merci, Stéphanie Solier, Velimir Gayevskiy, Marcel E. Dinger, Mark J. Cowley, Dorothée Selimoglu-Buet, Vincent Meyer, François Artiguenave, Jean-François Deleuze, Claude Preudhomme, Michael R. Stratton, Ludmil B. Alexandrov, Eric Padron, Seishi Ogawa, Serge Koscielny, Maria Figueroa, Eric Solary
Published 2016-02-01