Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis

Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis

Bone is innervated, and its turnover is affected by sympathetic nerve activity. Here, the authors show that prostaglandin E2, secreted by osteoblasts, activates the EP4 receptor on sensory nerves, inhibiting sympathetic nerve activity and modulating bone formation in mice.

Bibliographic Details
Main Authors: Hao Chen, Bo Hu, Xiao Lv, Shouan Zhu, Gehua Zhen, Mei Wan, Amit Jain, Bo Gao, Yu Chai, Mi Yang, Xiao Wang, Ruoxian Deng, Lei Wang, Yong Cao, Shuangfei Ni, Shen Liu, Wen Yuan, Huajiang Chen, Xinzhong Dong, Yun Guan, Huilin Yang, Xu Cao
Format: Article
Language:English
Published: Nature Publishing Group 2019-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-08097-7

Internet

https://doi.org/10.1038/s41467-018-08097-7

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