APE1/Ref‐1 knockdown in pancreatic ductal adenocarcinoma – characterizing gene expression changes and identifying novel pathways using single‐cell RNA sequencing

APE1/Ref‐1 knockdown in pancreatic ductal adenocarcinoma – characterizing gene expression changes and identifying novel pathways using single‐cell RNA sequencing

Apurinic/apyrimidinic endonuclease 1/redox factor‐1 (APE1/Ref‐1 or APE1) is a multifunctional protein that regulates numerous transcription factors associated with cancer‐related pathways. Because APE1 is essential for cell viability, generation of APE1‐knockout cell lines and determining a comprehe...

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Bibliographic Details
Main Authors: Fenil Shah, Emery Goossens, Nadia M. Atallah, Michelle Grimard, Mark R. Kelley, Melissa L. Fishel
Format: Article
Language:English
Published: Wiley 2017-12-01
Series:Molecular Oncology
Subjects:
APE1
pancreatic ductal adenocarcinoma
Ref‐1
RNA sequencing
single cell
Online Access:https://doi.org/10.1002/1878-0261.12138

Internet

https://doi.org/10.1002/1878-0261.12138

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