Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms

Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms

Aging impairs the activation of stress signaling pathways (SSPs), preventing the induction of longevity mechanisms late in life. Here, we show that the antibiotic minocycline increases lifespan and reduces protein aggregation even in old, SSP-deficient Caenorhabditis elegans by targeting cytoplasmic...

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Bibliographic Details
Main Authors: Gregory M Solis, Rozina Kardakaris, Elizabeth R Valentine, Liron Bar-Peled, Alice L Chen, Megan M Blewett, Mark A McCormick, James R Williamson, Brian Kennedy, Benjamin F Cravatt, Michael Petrascheck
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-11-01
Series:eLife
Subjects:
minocycline
lifespan extension
protein aggregation
neurodegenerative disease
ribosomal load
stress signaling
Online Access:https://elifesciences.org/articles/40314

Internet

https://elifesciences.org/articles/40314

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