TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens

TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens

TARM1 is a LILR family member that drives cell signalling via interactions with FcRγ. Here the authors show that TARM1 binds collagens to activate dendritic cells and thereby is an effector of inflammatory arthritis, plus provide a soluble TARM-Fc fusion protein that can limit collagen-induced arthr...

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Bibliographic Details
Main Authors: Rikio Yabe, Soo-Hyun Chung, Masanori A. Murayama, Sachiko Kubo, Kenji Shimizu, Yukiko Akahori, Takumi Maruhashi, Akimasa Seno, Tomonori Kaifu, Shinobu Saijo, Yoichiro Iwakura
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20307-9

Internet

https://doi.org/10.1038/s41467-020-20307-9

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