Biocatalytic Syntheses of Antiplatelet Metabolites of the Thienopyridines Clopidogrel and Prasugrel Using Fungal Peroxygenases

Biocatalytic Syntheses of Antiplatelet Metabolites of the Thienopyridines Clopidogrel and Prasugrel Using Fungal Peroxygenases

Antithrombotic thienopyridines, such as clopidogrel and prasugrel, are prodrugs that undergo a metabolic two-step bioactivation for their pharmacological efficacy. In the first step, a thiolactone is formed, which is then converted by cytochrome P450-dependent oxidation via sulfenic acids to the act...

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Bibliographic Details
Main Authors: Jan Kiebist, Kai-Uwe Schmidtke, Marina Schramm, Rosalie König, Stephan Quint, Johannes Kohlmann, Ralf Zuhse, René Ullrich, Martin Hofrichter, Katrin Scheibner
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Journal of Fungi
Subjects:
thienopyridine
clopidogrel
prasugrel
unspecific peroxygenase
human drug metabolites
antiplatelet
Online Access:https://www.mdpi.com/2309-608X/7/9/752

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https://www.mdpi.com/2309-608X/7/9/752

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