HCV 3a core protein increases lipid droplet cholesteryl ester content via a mechanism dependent on sphingolipid biosynthesis.

HCV 3a core protein increases lipid droplet cholesteryl ester content via a mechanism dependent on sphingolipid biosynthesis.

Hepatitis C virus (HCV) infected patients often develop steatosis and the HCV core protein alone can induce this phenomenon. To gain new insights into the pathways leading to steatosis, we performed lipidomic profiling of HCV core protein expressing-Huh-7 cells and also assessed the lipid profile of...

Full description

Bibliographic Details
Main Authors: Ursula Loizides-Mangold, Sophie Clément, Alba Alfonso-Garcia, Emilie Branche, Stéphanie Conzelmann, Clotilde Parisot, Eric O Potma, Howard Riezman, Francesco Negro
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0115309

Internet

https://doi.org/10.1371/journal.pone.0115309

Similar Items