TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p62-Dependent Selective Autophagy

TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p62-Dependent Selective Autophagy

The AIM2 inflammasome is a key cytosolic signaling complex that is activated by double-stranded DNA, leading to the maturation of proinflammatory cytokines such as interleukin-1β (IL-1β) and IL-18. Dysregulated AIM2 inflammasome activity is associated with human inflammatory diseases and cancers, su...

Full description

Bibliographic Details
Main Authors: Tao Liu, Qin Tang, Kunpeng Liu, Weihong Xie, Xin Liu, Huishan Wang, Rong-Fu Wang, Jun Cui
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:Cell Reports
Subjects:
AIM2 inflammasome
TRIM11
protein degradation
p62
selective autophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716309056

Internet

http://www.sciencedirect.com/science/article/pii/S2211124716309056

Similar Items