Yeast heterochromatin regulators Sir2 and Sir3 act directly at euchromatic DNA replication origins.

Yeast heterochromatin regulators Sir2 and Sir3 act directly at euchromatic DNA replication origins.

Most active DNA replication origins are found within euchromatin, while origins within heterochromatin are often inactive or inhibited. In yeast, origin activity within heterochromatin is negatively controlled by the histone H4K16 deacetylase, Sir2, and at some heterochromatic loci also by the nucle...

Full description

Bibliographic Details
Main Authors: Timothy A Hoggard, FuJung Chang, Kelsey Rae Perry, Sandya Subramanian, Jessica Kenworthy, Julie Chueng, Erika Shor, Edel M Hyland, Jef D Boeke, Michael Weinreich, Catherine A Fox
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-05-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC5991416?pdf=render

Internet

http://europepmc.org/articles/PMC5991416?pdf=render

Similar Items