Intestinal Growth in Glucagon Receptor Knockout Mice Is Not Associated With the Formation of AOM/DSS-Induced Tumors

Intestinal Growth in Glucagon Receptor Knockout Mice Is Not Associated With the Formation of AOM/DSS-Induced Tumors

Treatment with exogenous GLP-2 has been shown to accelerate the growth of intestinal adenomas and adenocarcinomas in experimental models of colonic neoplasia, however, the role of endogenous GLP-2 in tumor promotion is less well known. Mice with a global deletion of the glucagon receptor (Gcgr-/-) d...

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Bibliographic Details
Main Authors: Jenna Elizabeth Hunt, Mohammad Yassin, Jørgen Olsen, Bolette Hartmann, Jens Juul Holst, Hannelouise Kissow
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Endocrinology
Subjects:
GLP-2
AOM/DSS
glucagon receptor knockout
mice
intestinal growth
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.695145/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2021.695145/full

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