Downregulation of ATG5-dependent macroautophagy by chaperone-mediated autophagy promotes breast cancer cell metastasis

Downregulation of ATG5-dependent macroautophagy by chaperone-mediated autophagy promotes breast cancer cell metastasis

Abstract Recent data have shown that the expression of lysosome-associated membrane protein type 2 A (LAMP2A), the key protein in the chaperone-mediated autophagy (CMA) pathway, is elevated in breast tumor tissues. However, the exact effects and mechanisms of CMA during breast cancer metastasis rema...

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Bibliographic Details
Main Authors: Qi Han, Youcai Deng, Sha Chen, Rui Chen, Mingzhen Yang, Zhujun Zhang, Xiongshan Sun, Wei Wang, Ying He, Fangjie Wang, Xiaodong Pan, Peng Li, Wenjing Lai, Hongqin Luo, Pei Huang, Xiao Guan, Yafei Deng, Jun Yan, Xianjie Xu, Yan Wen, An Chen, Chuanmin Hu, Xiaohui Li, Shuhui Li
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-04994-x

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https://doi.org/10.1038/s41598-017-04994-x

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