KMT2A/C mutations function as a potential predictive biomarker for immunotherapy in solid tumors

Abstract Epigenetic factors play important roles in tumor immunology. Histone-lysine N-methyltransferase 2 (KMT2) family genes exert histone H3 methylation, but its role in immunotherapy remains unclear. Our study is the first to investigate the correlation between KMT2 gene mutations and the clinic...

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Bibliographic Details
Main Authors: Rui Zhang, Hao-Xiang Wu, Ming Xu, Xiaoyan Xie
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Biomarker Research
Subjects:
Online Access:https://doi.org/10.1186/s40364-020-00241-0