Pharmacodynamic and Pharmacokinetic Studies of β-Cyclodextrin:Dexamethasone Acetate Complexes in Mice

Pharmacodynamic and Pharmacokinetic Studies of β-Cyclodextrin:Dexamethasone Acetate Complexes in Mice

The aim of this study was to evaluate the in vivo activity of the anti-inflammatory and analgesic effects of a suspension of the complex composed of dexamethasone acetate (DMA) with β-cyclodextrin in comparison to a suspension of the pure DMA. Solid complexes prepared by different methods were evalu...

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Bibliographic Details
Main Authors: Patrik Oening Rodrigues, Ana Cláudia Becker, Viviane Aparecida Dellagnelo, Cibele Nabhan Benetti, Eduardo Manoel Pereira, Theodoro Marcel Wagner, Marcos Antonio Segatto Silva
Format: Article
Language:English
Published: Instituto de Tecnologia do Paraná (Tecpar) 2014-12-01
Series:Brazilian Archives of Biology and Technology
Subjects:
Solubility
dexamethasone acetate
β-cyclodextrin
bioavailability
anti-inflammatory activity
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132014000600887&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132014000600887&lng=en&tlng=en

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