Ferritin Light Chain Confers Protection Against Sepsis-Induced Inflammation and Organ Injury

Ferritin Light Chain Confers Protection Against Sepsis-Induced Inflammation and Organ Injury

Despite the prevalence and recognition of its detrimental impact, clinical complications of sepsis remain a major challenge. Here, we investigated the effects of myeloid ferritin heavy chain (FtH) in regulating the pathogenic sequelae of sepsis. We demonstrate that deletion of myeloid FtH leads to p...

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Bibliographic Details
Main Authors: Abolfazl Zarjou, Laurence M. Black, Kayla R. McCullough, Travis D. Hull, Stephanie K. Esman, Ravindra Boddu, Sooryanarayana Varambally, Darshan S. Chandrashekar, Wenguang Feng, Paolo Arosio, Maura Poli, Jozsef Balla, Subhashini Bolisetty
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
ferritin
inflammatory response
sepsis
NF-κB
cytokine
LPS
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00131/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00131/full

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