Foxp3 represses retroviral transcription by targeting both NF-kappaB and CREB pathways.
Forkhead box (Fox)/winged-helix transcription factors regulate multiple aspects of immune responsiveness and Foxp3 is recognized as an essential functional marker of regulatory T cells. Herein we describe downstream signaling pathways targeted by Foxp3 that may negatively impact retroviral pathogene...
| Format: | Article |
|---|---|
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2006-04-01
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| Series: | PLoS Pathogens |
| Online Access: | http://dx.doi.org/10.1371/journal.ppat.0020033 |