Reprogramming towards totipotency is greatly facilitated by synergistic effects of small molecules

Reprogramming towards totipotency is greatly facilitated by synergistic effects of small molecules

Animal cloning has been achieved in many species by transplanting differentiated cell nuclei to unfertilized oocytes. However, the low efficiencies of cloning have remained an unresolved issue. Here we find that the combination of two small molecules, trichostatin A (TSA) and vitamin C (VC), under c...

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Bibliographic Details
Main Authors: Kei Miyamoto, Yosuke Tajima, Koki Yoshida, Mami Oikawa, Rika Azuma, George E. Allen, Tomomi Tsujikawa, Tomomasa Tsukaguchi, Charles R. Bradshaw, Jerome Jullien, Kazuo Yamagata, Kazuya Matsumoto, Masayuki Anzai, Hiroshi Imai, John B. Gurdon, Masayasu Yamada
Format: Article
Language:English
Published: The Company of Biologists 2017-04-01
Series:Biology Open
Subjects:
Nuclear transfer
Reprogramming
Epigenetic modification
Mouse
Online Access:http://bio.biologists.org/content/6/4/415

Internet

http://bio.biologists.org/content/6/4/415

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