Combined use of metformin and atorvastatin attenuates atherosclerosis in rabbits fed a high-cholesterol diet

Abstract Statins are widely used to reduce cardiovascular risk. Unfortunately, some patients still experience cardiovascular events though prescribed with high-intensity statins. Metformin, an anti-diabetic drug, was reported to possess anti-atherosclerotic effects. Therefore, the experiments were d...

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Bibliographic Details
Main Authors: Fei Luo, Yuan Guo, Gui-yun Ruan, Jun-ke Long, Xi-long Zheng, Qin Xia, Shui-ping Zhao, Dao-quan Peng, Zhen-fei Fang, Xiang-ping Li
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-02080-w