Advanced Glycation End Product-Induced Astrocytic Differentiation of Cultured Neurospheres through Inhibition of Notch-Hes1 Pathway-Mediated Neurogenesis

Advanced Glycation End Product-Induced Astrocytic Differentiation of Cultured Neurospheres through Inhibition of Notch-Hes1 Pathway-Mediated Neurogenesis

This study aims to investigate the roles of the Notch-Hes1 pathway in the advanced glycation end product (AGE)-mediated differentiation of neural stem cells (NSCs). We prepared pLentiLox3.7 lentiviral vectors that express short hairpin RNA (shRNA) against Notch1 and transfected it into NSCs. Cell di...

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Bibliographic Details
Main Authors: Yijing Guo, Pin Wang, Haixia Sun, Rongrong Cai, Wenqing Xia, Shaohua Wang
Format: Article
Language:English
Published: MDPI AG 2013-12-01
Series:International Journal of Molecular Sciences
Subjects:
advanced glycation end products
neural stem cells
differentiation
Notch-Hes1 pathway
Online Access:http://www.mdpi.com/1422-0067/15/1/159

Internet

http://www.mdpi.com/1422-0067/15/1/159

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