Identification of AnnexinA1 as an Endogenous Regulator of RhoA, and Its Role in the Pathophysiology and Experimental Therapy of Type-2 Diabetes

Identification of AnnexinA1 as an Endogenous Regulator of RhoA, and Its Role in the Pathophysiology and Experimental Therapy of Type-2 Diabetes

Annexin A1 (ANXA1) is an endogenously produced anti-inflammatory protein, which plays an important role in the pathophysiology of diseases associated with chronic inflammation. We demonstrate that patients with type-2 diabetes have increased plasma levels of ANXA1 when compared to normoglycemic subj...

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Bibliographic Details
Main Authors: Gareth S. D. Purvis, Massimo Collino, Rodrigo A. Loiola, Andrea Baragetti, Fausto Chiazza, Martina Brovelli, Madeeha H. Sheikh, Debora Collotta, Alessia Cento, Raffaella Mastrocola, Manuela Aragno, Juan C. Cutrin, Chris Reutelingsperger, Liliana Grigore, Alberico L. Catapano, Magdi M. Yaqoob, Giuseppe Danilo Norata, Egle Solito, Christoph Thiemermann
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
type-2 diabetes
metabolism
Annexin A1
nephropathy
hepatosteatosis
Rho A
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00571/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00571/full

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