An high-throughput in vivo screening system to select H3K4-specific histone demethylase inhibitors.

An high-throughput in vivo screening system to select H3K4-specific histone demethylase inhibitors.

Histone demethylases (HDMs) have a prominent role in epigenetic regulation and are emerging as potential therapeutic cancer targets. The search for small molecules able to inhibit HDMs in vivo is very active but at the present few compounds were found to be specific for defined classes of these enzy...

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Bibliographic Details
Main Authors: Cecilia Mannironi, Marco Proietto, Francesca Bufalieri, Enrico Cundari, Angela Alagia, Svetlana Danovska, Teresa Rinaldi, Valeria Famiglini, Antonio Coluccia, Giuseppe La Regina, Romano Silvestri, Rodolfo Negri
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3906020?pdf=render

Internet

http://europepmc.org/articles/PMC3906020?pdf=render

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