Combined antigen-specific interferon-γ and interleukin-2 release assay (FluoroSpot) for the diagnosis of Mycobacterium tuberculosis infection.

To evaluate interleukin (IL)-2 and interferon (IFN)-γ secreting T-cells in parallel for the differentiation of latent infection with Mycobacterium tuberculosis infection (LTBI) from active tuberculosis.Following ex-vivo stimulation of peripheral blood mononuclear cells (PBMC) with M. tuberculosis-sp...

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Bibliographic Details
Main Authors: Dumitru Chesov, Christoph Lange, Franziska Daduna, Valeriu Crudu, Rosemarie Preyer, Martin Ernst, Barbara Kalsdorf
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4364905?pdf=render