Computational modeling of interacting VEGF and soluble VEGF receptor concentration gradients

Computational modeling of interacting VEGF and soluble VEGF receptor concentration gradients

Experimental data indicates that soluble VEGF receptor 1 (sFlt-1) modulates the guidance cues provided to sprouting blood vessels by vascular endothelial growth factor-A (VEGF). To better delineate the role of sFlt-1 in VEGF signaling, we have developed an experimentally-based computational model....

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Bibliographic Details
Main Authors: Yasmin L Hashambhoy, John C Chappell, Shayn M Peirce, Victoria L Bautch, Feilim eMac Gabhann
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-10-01
Series:Frontiers in Physiology
Subjects:
Developmental Biology
computational model
mathematical model
VEGF
Angiogenesis
Vascular Development
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2011.00062/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2011.00062/full

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