Deleterious alleles in the human genome are on average younger than neutral alleles of the same frequency.

Deleterious alleles in the human genome are on average younger than neutral alleles of the same frequency.

Large-scale population sequencing studies provide a complete picture of human genetic variation within the studied populations. A key challenge is to identify, among the myriad alleles, those variants that have an effect on molecular function, phenotypes, and reproductive fitness. Most non-neutral v...

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Bibliographic Details
Main Authors: Adam Kiezun, Sara L Pulit, Laurent C Francioli, Freerk van Dijk, Morris Swertz, Dorret I Boomsma, Cornelia M van Duijn, P Eline Slagboom, G J B van Ommen, Cisca Wijmenga, Genome of the Netherlands Consortium, Paul I W de Bakker, Shamil R Sunyaev
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3585140?pdf=render

Internet

http://europepmc.org/articles/PMC3585140?pdf=render

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