Bioactive Secondary Metabolites of a Marine Bacillus sp. Inhibit Superoxide Generation and Elastase Release in Human Neutrophils by Blocking Formyl Peptide Receptor 1

Bioactive Secondary Metabolites of a Marine Bacillus sp. Inhibit Superoxide Generation and Elastase Release in Human Neutrophils by Blocking Formyl Peptide Receptor 1

It is well known that overwhelming neutrophil activation is closely related to acute and chronic inflammatory injuries. Formyl peptide receptor 1 (FPR1) plays an important role in activation of neutrophils and may represent a potent therapeutic target in inflammatory diseases. In the present study,...

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Bibliographic Details
Main Authors: Yin-Ting Huang, Tsong-Long Hwang, Pei-Jen Chung, Jimmy Kuo, Shun-Chin Yang, Wen-Yi Chang, Chwan-Fwu Lin
Format: Article
Language:English
Published: MDPI AG 2013-06-01
Series:Molecules
Subjects:
elastase
formyl peptide receptor
Bacillus sp.
neutrophil
superoxide
Online Access:http://www.mdpi.com/1420-3049/18/6/6455

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http://www.mdpi.com/1420-3049/18/6/6455

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