Cytosine arabinoside-metabolizing enzyme genes are underexpressed in children with MLL gene-rearranged acute lymphoblastic leukemia

Cytosine arabinoside-metabolizing enzyme genes are underexpressed in children with MLL gene-rearranged acute lymphoblastic leukemia

Infant acute lymphoblastic leukemia (IALL) is characterized by mixed lineage leukemia (MLL) gene rearrangements, unique gene expression profiles, poor prognosis, and drug resistance. One exception is cytosine arabinoside (Ara-C) to which IALL cells seem to be more sensitive. We quantified mRNA expre...

Full description

Bibliographic Details
Main Authors: J.F. Mata, C.A. Scrideli, R.P. Queiroz, B.O. Mori, M. Emerenciano, M.S. Pombo-de-Oliveira, L.G. Tone
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2006-11-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Cytosine arabinoside
Acute lymphoblastic leukemia
Infant
Mixed lineage leukemia gene rearrangement
Gene expression
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006001100005

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006001100005

Similar Items