Renoprotection Provided by Additional Diuretic Treatment in Partially Nephrectomized Ren-2 Transgenic Rats Subjected to the Combined RAS and ETA Blockade

Renoprotection Provided by Additional Diuretic Treatment in Partially Nephrectomized Ren-2 Transgenic Rats Subjected to the Combined RAS and ETA Blockade

ObjectiveOur previous study in heterozygous Ren-2 transgenic rats (TGR) demonstrated that long-term treatment with endothelin receptor A (ETA) blocker atrasentan added to the renin-angiotensin system (RAS) blockade had renoprotective effects in a model of chronic kidney disease (CKD) induced by part...

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Bibliographic Details
Main Authors: Ivana Vaněčková, Silvie Hojná, Zdenka Vernerová, Michaela Kadlecová, Hana Rauchová, Elzbieta Kompanowska-Jezierska, Zdeňka Vaňourková, Luděk Červenka, Josef Zicha
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Physiology
Subjects:
hydrochlorothiazide
renoprotection
nephrectomy
atrasentan
chronic kidney disease
losartan
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.01145/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.01145/full

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