KSHV infection drives poorly cytotoxic CD56-negative natural killer cell differentiation in vivo upon KSHV/EBV dual infection

KSHV infection drives poorly cytotoxic CD56-negative natural killer cell differentiation in vivo upon KSHV/EBV dual infection

Summary: Herpesvirus infections shape the human natural killer (NK) cell compartment. While Epstein-Barr virus (EBV) expands immature NKG2A+ NK cells, human cytomegalovirus (CMV) drives accumulation of adaptive NKG2C+ NK cells. Kaposi sarcoma-associated herpesvirus (KSHV) is a close relative of EBV,...

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Bibliographic Details
Main Authors: Nicole Caduff, Donal McHugh, Lisa Rieble, Catherine S. Forconi, John M. Ong’echa, Peter O. Oluoch, Ana Raykova, Anita Murer, Michelle Böni, Lara Zuppiger, Thomas F. Schulz, David J. Blackbourn, Obinna Chijioke, Ann M. Moormann, Christian Münz
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Cell Reports
Subjects:
Kaposi sarcoma-associated herpesvirus
KSHV
Epstein-Barr virus
EBV
humanized mouse model
natural killer cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721003727

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http://www.sciencedirect.com/science/article/pii/S2211124721003727

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