The Drosophila junctophilin gene is functionally equivalent to its four mammalian counterparts and is a modifier of a Huntingtin poly-Q expansion and the Notch pathway

The Drosophila junctophilin gene is functionally equivalent to its four mammalian counterparts and is a modifier of a Huntingtin poly-Q expansion and the Notch pathway

Members of the Junctophilin (JPH) protein family have emerged as key actors in all excitable cells, with crucial implications for human pathophysiology. In mammals, this family consists of four members (JPH1-JPH4) that are differentially expressed throughout excitable cells. The analysis of knockout...

Full description

Bibliographic Details
Main Authors: Eduardo Calpena, Víctor López del Amo, Mouli Chakraborty, Beatriz Llamusí, Rubén Artero, Carmen Espinós, Máximo I. Galindo
Format: Article
Language:English
Published: The Company of Biologists 2018-01-01
Series:Disease Models & Mechanisms
Subjects:
Junctophilin
Drosophila
Cardiomyopathy
Huntington's disease
Notch
Online Access:http://dmm.biologists.org/content/11/1/dmm029082

Internet

http://dmm.biologists.org/content/11/1/dmm029082

Similar Items