In silico Design of Phl p 6 Variants With Altered Fold-Stability Significantly Impacts Antigen Processing, Immunogenicity and Immune Polarization

In silico Design of Phl p 6 Variants With Altered Fold-Stability Significantly Impacts Antigen Processing, Immunogenicity and Immune Polarization

Introduction: Understanding, which factors determine the immunogenicity and immune polarizing properties of proteins, is an important prerequisite for designing better vaccines and immunotherapeutics. While extrinsic immune modulatory factors such as pathogen associated molecular patterns are well-u...

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Bibliographic Details
Main Authors: Petra Winter, Stefan Stubenvoll, Sandra Scheiblhofer, Isabella A. Joubert, Lisa Strasser, Carolin Briganser, Wai Tuck Soh, Florian Hofer, Anna Sophia Kamenik, Valentin Dietrich, Sara Michelini, Josef Laimer, Peter Lackner, Jutta Horejs-Hoeck, Martin Tollinger, Klaus R. Liedl, Johann Brandstetter, Christian G. Huber, Richard Weiss
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
structural stability
endolysosomal degradation
antigen processing and presentation
protein stabilization
immune polarization
in silico mutagenesis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01824/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01824/full

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