Synthesis, density functional theory (DFT) studies and urease inhibition activity of chiral benzimidazoles

Synthesis, density functional theory (DFT) studies and urease inhibition activity of chiral benzimidazoles

A variety of benzimidazole by the heterocyclization of orthophenylenediamine were synthesized in 69–86% yields. The synthesized compounds 3a-f and 6a-f were characterized and further investigated as jack bean urease inhibitors. Density functional theory (DFT) studies were performed utilizing the bas...

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Bibliographic Details
Main Authors: Hasil Aman, Naghmana Rashid, Zaman Ashraf, Aamna Bibi, Hsin-Tsung Chen, Nadaraj Sathishkumar
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Heliyon
Subjects:
Organic chemistry
Pharmaceutical chemistry
Theoretical chemistry
Benzimidazole
Urease inhibition
Density functional theory
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844020320302

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http://www.sciencedirect.com/science/article/pii/S2405844020320302

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