The metabolic enzyme fructose-1,6-bisphosphate aldolase acts as a transcriptional regulator in pathogenic Francisella

The metabolic enzyme fructose-1,6-bisphosphate aldolase acts as a transcriptional regulator in pathogenic Francisella

The enzyme fructose-bisphosphate aldolase (FBA) plays central roles in glycolysis and gluconeogenesis. Here, Ziveri et al. show that FBA of the pathogen Francisella novicida acts, in addition, as a transcriptional regulator and is important for bacterial multiplication in macrophages.

Bibliographic Details
Main Authors: Jason Ziveri, Fabiola Tros, Ida Chiara Guerrera, Cerina Chhuon, Mathilde Audry, Marion Dupuis, Monique Barel, Sarantis Korniotis, Simon Fillatreau, Lara Gales, Edern Cahoreau, Alain Charbit
Format: Article
Language:English
Published: Nature Publishing Group 2017-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00889-7

Internet

https://doi.org/10.1038/s41467-017-00889-7

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