Contribution of tissue transglutaminase to the severity of hepatic fibrosis resulting from Schistosoma japonicum infection through the regulation of IL-33/ST2 expression

Contribution of tissue transglutaminase to the severity of hepatic fibrosis resulting from Schistosoma japonicum infection through the regulation of IL-33/ST2 expression

Abstract Background Tissue transglutaminase (tTG)-regulating IL-13 plays an important role in the pathogenesis of liver fibrosis resulting from Schistosoma japonicum (Sj) infection. IL-33 and its receptor ST2 are involved in Th2-biased immune responses through the release of IL-5 and IL-13 and subse...

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Main Authors: Zhi-Yong Li, LinZhuo Xiao, GuiYing Lin, JuanJuan Tang, YuQiang Chen, Lan Chen, BaoQi Li, MeiLing Wu, ShuYan Liu, ChuQin Huang, Dominique Ferrandon, Zi Li
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Parasites & Vectors
Subjects:
Tissue transglutaminase
IL-33
ST2
Liver fibrosis
Schistosoma japonicum
Online Access:http://link.springer.com/article/10.1186/s13071-019-3542-4

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http://link.springer.com/article/10.1186/s13071-019-3542-4

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