Histone deacetylase 7 mediates endothelin-1-induced connective tissue growth factor expression in human lung fibroblasts through p300 and activator protein-1 activation

Histone deacetylase 7 mediates endothelin-1-induced connective tissue growth factor expression in human lung fibroblasts through p300 and activator protein-1 activation

Abstract Background Histone deacetylase (HDAC) inhibition was reported to ameliorate lung fibrosis in animal models. However, little is known about the underlying mechanism of HDAC7 in the regulation of CTGF production in lung fibroblasts. Methods The role of HDAC7 in CTGF production caused by ET-1...

Full description

Bibliographic Details
Main Authors: Hung-Sheng Hua, Heng-Ching Wen, Chih-Ming Weng, Hong-Sheng Lee, Bing-Chang Chen, Chien-Huang Lin
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Journal of Biomedical Science
Subjects:
HDAC7
ET-1
CTGF
Airway fibrosis
Lung fibroblasts
Online Access:https://doi.org/10.1186/s12929-021-00735-5

Internet

https://doi.org/10.1186/s12929-021-00735-5

Similar Items