Deletion of the murine cytochrome P450 Cyp2j locus by fused BAC-mediated recombination identifies a role for Cyp2j in the pulmonary vascular response to hypoxia.

Deletion of the murine cytochrome P450 Cyp2j locus by fused BAC-mediated recombination identifies a role for Cyp2j in the pulmonary vascular response to hypoxia.

Epoxyeicosatrienoic acids (EETs) confer vasoactive and cardioprotective functions. Genetic analysis of the contributions of these short-lived mediators to pathophysiology has been confounded to date by the allelic expansion in rodents of the portion of the genome syntenic to human CYP2J2, a gene enc...

Full description

Bibliographic Details
Main Authors: Guo Ling Zhou, Arkadi Beloiartsev, Binglan Yu, David M Baron, Weihua Zhou, Rasma Niedra, Naifang Lu, Laurel T Tainsh, Warren M Zapol, Brian Seed, Kenneth D Bloch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-11-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3836722?pdf=render

Internet

http://europepmc.org/articles/PMC3836722?pdf=render

Similar Items