Structural Characterization of de Novo Designed L5K5W Model Peptide Isomers with Potent Antimicrobial and Varied Hemolytic Activities

Structural Characterization of de Novo Designed L5K5W Model Peptide Isomers with Potent Antimicrobial and Varied Hemolytic Activities

In an effort to develop short antimicrobial peptides with simple amino acid compositions, we generated a series of undecapeptide isomers having the L5K5W formula. Amino acid sequences were designed to be perfectly amphipathic when folded into a helical conformation by converging leucines onto one si...

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Bibliographic Details
Main Authors: Sung-Jean Park, Bong-Jin Lee, Kwang-Ho Lee, Eun-Hee Kim, Young-Yil Bahk, Sung-Hee Lee, Dae-Won Sim, Yoo-Sup Lee, Jae-Seok Kim, Seo-Jin Kim, Hyung-Sik Won
Format: Article
Language:English
Published: MDPI AG 2013-01-01
Series:Molecules
Subjects:
amphipathic helical peptides
antimicrobial peptides
de novo design
hemolytic activity
L5K5W isomers
structure-activity relationships
tryptophan
Online Access:http://www.mdpi.com/1420-3049/18/1/859

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http://www.mdpi.com/1420-3049/18/1/859

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