Identification of Familial Hodgkin Lymphoma Predisposing Genes Using Whole Genome Sequencing

Identification of Familial Hodgkin Lymphoma Predisposing Genes Using Whole Genome Sequencing

Hodgkin lymphoma (HL) is a lymphoproliferative malignancy of B-cell origin that accounts for 10% of all lymphomas. Despite evidence suggesting strong familial clustering of HL, there is no clear understanding of the contribution of genes predisposing to HL. In this study, whole genome sequencing (WG...

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Bibliographic Details
Main Authors: Aayushi Srivastava, Sara Giangiobbe, Abhishek Kumar, Nagarajan Paramasivam, Dagmara Dymerska, Wolfgang Behnisch, Mathias Witzens-Harig, Jan Lubinski, Kari Hemminki, Asta Försti, Obul Reddy Bandapalli
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
familial Hodgkin lymphoma
whole genome sequencing
predisposing genes
germline variants
variant prioritization
next generation sequencing
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00179/full

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https://www.frontiersin.org/article/10.3389/fbioe.2020.00179/full

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