Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts.

Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts.

PINK1 and Parkin mutations cause recessive Parkinson's disease (PD). In Drosophila and SH-SY5Y cells, Parkin is recruited by PINK1 to damaged mitochondria, where it ubiquitinates Mitofusins and consequently promotes mitochondrial fission and mitophagy.Here, we investigated the impact of mutatio...

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Bibliographic Details
Main Authors: Aleksandar Rakovic, Anne Grünewald, Jan Kottwitz, Norbert Brüggemann, Peter P Pramstaller, Katja Lohmann, Christine Klein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3050809?pdf=render

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http://europepmc.org/articles/PMC3050809?pdf=render

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