Estradiol Attenuates the Severity of Primary Toxoplasma gondii Infection-Induced Adverse Pregnancy Outcomes Through the Regulation of Tregs in a Dose-Dependent Manner

Estradiol Attenuates the Severity of Primary Toxoplasma gondii Infection-Induced Adverse Pregnancy Outcomes Through the Regulation of Tregs in a Dose-Dependent Manner

Estradiol (E2) plays a crucial and intricate role during pregnancy to mediate several aspects of the pregnancy process. A perplexing phenomenon in congenital toxoplasmosis is that the severity of Toxoplasma gondii (T. gondii)-mediated adverse pregnancy outcome is closely related with time of primary...

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Bibliographic Details
Main Authors: Jingfan Qiu, Rong Zhang, Yanci Xie, Lijuan Wang, Ke Ge, Hao Chen, Xinjian Liu, Jiangping Wu, Yong Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
estradiol
Toxoplasma gondii
regulatory T cells
programmed death-1
abortion
apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01102/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01102/full

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