Elucidation of the Clustered Nano-Architecture of Radiation-Induced DNA Damage Sites and Surrounding Chromatin in Cancer Cells: A Single Molecule Localization Microscopy Approach

Elucidation of the Clustered Nano-Architecture of Radiation-Induced DNA Damage Sites and Surrounding Chromatin in Cancer Cells: A Single Molecule Localization Microscopy Approach

In cancer therapy, the application of (fractionated) harsh radiation treatment is state of the art for many types of tumors. However, ionizing radiation is a “double-edged sword”—it can kill the tumor but can also promote the selection of radioresistant tumor cell clones or even initiate carcinogene...

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Bibliographic Details
Main Authors: Michael Hausmann, Martin Falk, Charlotte Neitzel, Andreas Hofmann, Abin Biswas, Theresa Gier, Iva Falkova, Dieter W. Heermann, Georg Hildenbrand
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
topology of DNA double strand breaks
nano-architecture
ionizing radiation-induced foci (IRIF)
chromatin rearrangements after irradiation
single molecule localization microscopy (SMLM)
Online Access:https://www.mdpi.com/1422-0067/22/7/3636

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https://www.mdpi.com/1422-0067/22/7/3636

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